FSH & LH

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taken from wikipedia

Activity

FSH regulates the development, growth, pubertal maturation, and reproductive processes of the human body.

• In both males and females, FSH stimulates the maturation of germ cells.

• In males, FSH induces Sertoli cells to secrete inhibin and stimulates the formation of sertoli-sertoli tight junctions (zonula occludens).

• In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B, FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle.

Like its partner LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin-releasing hormone (GnRH). Those pulses, in turn, are subject to the oestrogen feed-back from the gonads.

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i've heard of this. but never thought of that it is related to ovulation. i think im lack of FSH or LH. sebab tu dia tak release. and stuck. and mr. PCOS came.

FSH stimulates the growth and recruitment of immature Ovarian follicles in the ovary. In early (small) antral follicles, FSH is the major survival factor that rescues the follicles fromapoptosis (programmed death of the somatic cells of the follicle and oocyte). In the luteal-follicle phase transition period the serum levels of progesterone and estrogen (primarily estradiol) decrease and no longer suppress the release of FSH, consequently FSH peaks at about day three (day one is the first day of menstrual flow). The cohort of small antral follicles is normally sufficiently in number to produce enough Inhibin B to lower FSH serum levels.

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When the follicle matures and reaches 8-10 mm in diameter it starts to secrete significant amounts of estradiol. Normally in humans only one follicle becomes dominant and survives to grow to 18-30 mm in size and ovulate, the remaining follicles in the cohort undergo atresia.

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So now i know when Dr Karamjeet did the sonogram on me to check the development after clomid response, dia ckp my follicles were only 10-12mm. tak cukop size.

so there is no point of injection kot. rasenye dia kena inject FSH/LH ni la.

FSH ni maybe sbb mahal, so dia tak inject dulu. LPPKN pon dah 100++, kalau private maybe lebeh lagi la.

takpe i'll remember to ask about FSH/LH injection lepas ni. if i need it or not.

aku rase yg plg tepat ialah LH kot. LH ni la keje dia utk mem-BURST-kan follicle supaye keluarnye ovum utk ke falopion tube. Pil perancang halang pengeluaran hormon LH. sebab tu la follicle tu tak pecah utk discharge an ovum. HISH aku ni buat ape tah mase sains kat skolah dulu! takpasal2 aku buat rumusan psl benda yg dah blaja dulu2 plak..hehehe.

so, period terjadi sebab CORPUS LUTEUM (follicle yg dah mati dan ovum di dalamnye tidak dilepaskan) jadi darah.

so, a normal period pon, doesnt mean that we ovulated. so we need the LH!

tapi tak jugak. i also need FSH sebab gunanya utk membesarkan follicles..hm betol2..tugas CLOMID pon dah mmg utk stimulate FSH & LH tinggal lagi aku ni tak cukop 100mg tu. sbb tu la kene up lagi. and if necessary, needs the FSH/LH injection. optional kot injection tu. alaa PCOS have nothing to do with whether i got the injections or not laa. its not bcoz of i didnt get injected i got PCOS. aku mmg ada penyaket PCOS tu and injection doesnt make anything better. kalau aku dpt injection tu pon, follicles aku kecik. mane boleh ovulate? buatpe doc nak inject pon kan?

agaknye dr sudha tanye sbb just nak make sure kot. sbb dah aku ckp aku dpt positive lepas tu kan. and maybe akak2 opis aku dpt injection tu sbb follicles dia cukop besar!

ok.

sudah

faham.

sekian.