New friend - Femara

Jumaat lepas (30/7/2010) aku gi klinik UMRA balik. sebab nak inform doctor yg aku dah habis Diane35 on 29th july tu and nak collect another cycle of Diane35 and Clomid 150mg. -konpiden nak mintak clomid aku nih.haha

then aku sgt suka sbb doctor yg ada hari tu ialah Dr Sudha lagi skali. aku rase die mmg ade setiap ptg jumaat before 630pm. so lepas ni aku akan dtg ptg jumaat je lah!

Dr Sudha gitau yg die mmg akan bagi Diane35 lagi tapi die takkan bagi Clomid dah. sbb die ckp based on Dr Karamjeet nye report dlm aku nye record tuh, aku nye follicles mase ambik clomid dulu terlalu kecik sgt. so aku may not respond to clomid dgn bagos. so no point of up dose lagi. mmg boleh tapi terlalu kecik sgt mase aku ambik clomid 100mg tu. so die ckp tak berbaloi try utk benda yg kite dah mmg tau kite takleh respon.

pastu aku tanye Then nak kasi apa?

dia ckp Letrozole.

aku cam HaaaA?

LETROZOLE

sumpah takpenah dgr. ni pelik gak ni aku takpenah dgr sedangkan hari2 aku google psl fertility drugs.

die ckp org yg tak respon dgn clomid mmg doctor akan tukar kpd Letrozole and ramai org yg tak respon to clomid, is responding well with letrozole. aku pon cam Ok la what she thinks the best.

then die kate kali ni aku mmg perlukan bantuan injections.

aku tanye injection ape nak bagi?

Gonal-F and HCG to break the egg.

Gonal-F tu aku mmg penah dgr. aku pon baru nak tanye doctor, tapi die dah ckp dah aku mmg kene ambik. memandangkan hormon reproductive aku ni mmg sgt sikit atau tak balance atau aku pon tattau!

benda tu hari hari kene inject sampai 7hari. aku tattau mcm mana nak inject tu sbb ade yg aku google kite leh buat sendri bende tu. ape2 pon bagi aku period sampai 2nd cycle of diane35 ni dulu baru aku leh dtg klinik balik utk tanye psl injection2 ni. harap2 time tu Dr Sudha ade la. aku takmo jumpe doctor2 lain kat situ dah. semua bagi aku information yg sgt susah aku nak paham sampai aku salah paham.

aku ade tanye doctor, falopion tube aku sumbat tak?

die ckp I also donno if your tube is sumbat or not. because to reach that point, u MUST MUST have good ovaries first. if your ovaries are not ovulating regularly then there is no point checking for your tubes. so we are not there yet :)

OoOOOO baru la aku paham. yg penting penting penting skali ialah ovary aku.

kalau ovary semua ok, tak pregnant gak, baru leh investigate tube.

jaoh sunggoh perjalanan aku..

well, im actually enjoying it. walaupon aku kdg2 penat. tapi aku takleh putus asa..

doakan aku eh :)

---

hari ni aku masok ofis aku teros google Letrozole tu menatang apa.

laaa

FEMARA rupenye! femara tu name brand dia. name saintifik dia letrozole..kalau femara aku mmg penah dgr laaa..!

klinik tu tak boh tablet tu dlm kotak, tapi dlm plastik ubat mcm biasa tu..so tattau ape brand name dia..aku kene ambik 5mg sehari for 5 days starting 2nd cycle period (with diane) nnt.

ABOUT FEMARA

Femara (Letrozole) for Infertility, Ovulation Problems and PCOS Treatment

What is Femara - Letrozole?

• Femara (generic name is letrozole) is an oral drug which can be an effective fertility treatment for women with ovulation problems, or for those with unexplained infertility.


• This medication is in a class of drug called aromatase inhibitors. Femara has mainly been used to treat certain cases of breast cancer.

This page is about the use of Femara for infertility

How are Femara and Letrozole Used as a Fertility Drug?

Femara to Induce Ovulation

• When the enzyme aromatase is inhibited by the letrozole medication, estrogen levels are suppressed in young women. This results in the brain and pituitary gland increasing the output of FSH (follicle stimulating hormone).


• In women that have polycystic ovary syndrome or anovulation (a problem with ovulation) the increase in FSH hormone can result in development of a mature follicle in the ovary and ovulation of an egg. Doctors call this process "induction of ovulation".

Femara to Increase Pregnancy Chances in Ovulating Women

• In women that already ovulate on their own, treatment with Femara can result in development of multiple follicles and multiple eggs releasing.


• Release of multiple eggs can increase the chances for pregnancy as compared to release of a single egg with a natural menstrual cycle.


• Doctors refer to the process of stimulating ovulation of multiple follicles and eggs as superovulation, or controlled ovarian hyperstimulation.

Femara to Treat Infertility After Clomid Attempts Fail

Femara vs. Clomid

Clomid (brand name) or clomiphene citrate (generic name) is an oral medication that is often used for stimulating ovulation in women that do not ovulate on their own. Femara has sometimes been used in these women as an alternative to clomiphene.

Some women will not respond to Clomid at all.

Letrozole can induce ovulation in some of these women.

• Women that do ovulate with Clomid still might never get pregnant with it.


• Some of these women will conceive with letrozole


• There can be unpleasant side effects with Clomid that cause women to stop taking it


• This can be a reason to use Femara instead of Clomid

Femara and Pregnancy - Success Rates Using Femara and Letrozole

• Monthly chances for getting pregnant using letrozole are about the same as they are for using Clomid.


• Much will depend on the age of the female partner and on the status of the fallopian tubes and the male's sperm quality.


• Higher Success for Women Not Ovulating on Their Own


• With the following conditions, we can expect approximately 15% per month for a chance to get pregnant with Femara:


• No other fertility issues are present


• The female partner is under 35 years old


• We achieve ovulation with the letrozole in a woman that was not ovulating


• Lower Success for Unexplained Fertility in Ovulating Women


• When it is being used for unexplained infertility in a woman who ovulates regularly on her own, the expectations for success are significantly lower than that.

Femara and IUI

Whether it is being used in unexplained infertility, or to induce ovulation, adding intrauterine insemination (IUI) and Femara together significantly improves chances for pregnancy.

Femara and Letrozole Dosing

• The most common dose of Femara is 2.5 mg per day on days five through nine of the menstrual cycle.


• Sometimes it is given in higher doses of 5 mg or 7.5 mg per day.

Risks and Side Effects of Femara

Report on Higher Incidence of Birth Defects

• Many physicians will not prescribe letrozole because of concerns from a 2005 report from some Canadian fertility doctors suggesting a possible higher incidence of birth defects in pregnancies from using letrozole.


• This study was from a small group of pregnancies and the study has been severely criticized for having an improper design.


• Femara is known to have a short half-life in the bloodstream and is given early in the menstrual cycle - several days before a fertilized embryo is present. It is believed that the drug has cleared from the system before the egg is fertilized. Therefore, it is puzzling as to what mechanism could be responsible for the drug causing birth defects.


• The manufacturer of letrozole sent a warning to doctors saying there are reported birth defects in children born after mothers took Femara. This may have been due to liability concerns (lawyers and financial risks for a drug company) rather than real science.


• The manufacturer of the drug has apparently not filed for FDA approval to use it for infertility. However, physicians often use medications in an "off label" way. When the off label use is safe and effective it is perfectly legitimate.

Is Femara Prescribed by Fertility Specialists?

• Some fertility specialists or gynecologists will not prescribe Femara


• Others will use it - after explaining to the patient that there has been concerns raised regarding the potential for increased rates of birth defects